Endocrine Abstracts

Exogenous corticotropin-releasing factor (CRF) induces an increase in glucocorticoid production and also may protect the gastric mucosa against stress-induced injury. However, it remained unknown whether glucocorticoids released in response to CRF injection contribute to the gastroprotective effect of CRF. In the present study we investigated whether exogenous CRF may protect the gastric mucosa against gastric injury through involvement of glucocorticoids and, consequently, th...